Adenosín difosfato

"ADP" redirects here. For other uses of the acronym, see Aéroports de Paris.

Adenosine diphosphate (ADP) is a nucleoside diphosphate, ie a chemical compound formed by a nucleoside and two phosphate radicals linked together. In this case the nucleoside is made up of a purified base, adenine, and a sugar of the pentose type which is ribose.

It can be considered as the unphosphorylated part of ATP. ADP occurs when there is some decarboxylation in some of the compounds of glycolysis in the Krebs cycle.

ADP is stored in the dense granules of platelets, and is mobilized by platelet activation. ADP interacts with the family of ADP receptors found in platelets (P2Y1, P2Y12 and P2X1), directing more platelet activation. ADP in the blood is converted to adenosine by the action of ecto-ADPases, and thus inhibiting more platelet activation via the adenosine receptor. The antiplatelet drug Plavix (clopidogrel) inhibits the P2Y12 receptor.

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