Fetal Valproic Acid Syndrome

Valproic acid syndrome or valproic acid embryopathy is a set of congenital malformations present in a fetus due to exposure during the first trimester of pregnancy to valproic acid, mainly neural tube defects such as spina bifida, cardiovascular anomalies congenital, genital abnormalities, eg, hypospadias, or defects in the toes. Pathogeny

It is well documented that valproic acid or valproate is a teratogen. Several factors contribute to the teratogenicity of valproic acid. These include the number of drugs given together with valproate, the dose of the drug, the differences between maternal and infant metabolism, and the gestational age of the fetus at the time of exposure. epilepsy in the mother could be teratogenic in and of itself. Babies of epileptic mothers are particularly prone to such birth defects. Of greater concern is the possibility of teratogenesis due to exposure to anticonvulsant drugs. As a rule, they often cause some teratogenic patterns specific to birth defects.

[[Category: Pediatric diseases

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