Chemotactic selection

Chemotaxis receptors are expressed on the surface of the membrane with various dynamics, some of them have long-term characteristics, as they are genetically determined; others have short-term elements because their function induces & lt; ad hoc & gt; & gt; in the presence of the ligand. The characteristic diversity of chemotactic and ligand receptors offers the possibility of selecting chemotactic response cells (target cells) with a simple chemotaxis assay. By chemotactic selection we can determine if a molecule is not yet characterized by actions through long or short duration receptors. Recent results have shown that chemokines (eg, IL-8, RANTES) act on long-lived chemotactic receptors, whereas vasoactive peptides (eg, endothelin) act on short-term peptides. The term chemotactic is also used for a design of a technique that separates eukaryotic or prokaryotic cells from their selective chemotactic selective ligands.

Kohidai L and Csaba G (1988). «Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF alpha) in the unicellular Tetrahymena pyriformis.». Cytokine 10: 481-6. 

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