Cordotonal neurons are a type of neuron that arises during the generation of the peripheral nervous system. These are mechanical stress receptors that act as proprioceptors and auditory sensory cells. During embryonic development they travel through the embryo until they are grouped together to generate precursors of sensory organs (SOP). These monodendritic neurons are organized giving rise to the scolopidia, essential units of the cordotonal organs. The sensory elements of Drosophila are divided into external sensory organs, neurons with multiple dendrites, photoreceptors and cordotonal neurons. While the first two types require the activation of proneural genes of the achaete / scute complex these neurons are differentiated due to the action of the atonal neurogenic gene. Atonal is the gene that originates the first precursors also activating spitz. This is an epidermal growth factor receptor (EGF) ligand, when it binds to it, the second precursors are generated in which the pointed genes and argos are responsible for recruiting new epidermal cells for differentiation into cordotonal neurons.
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