Scleroderma

This article is about the disease. For the mushroom, see Scleroderma (genus). Not to be confused with the skin disease scleredema.

Scleroderma is an old systemic and autoimmune disease in which fibrosis (or stiffness), blood cellular changes and autoimmunity are observed. There are two main types:

Dermal manifestations of limited systemic sclerosis / scleroderma affect primarily hands, arms and face. The to the following complications were first known as crest syndrome: calcium, rhenod phenomina, food hose disease, sclerodactyly and telengiciatiasius. In addition, pulmonary arterial hypertension may occur to one third of patients and this can be the most serious complication for this form of scleroderma.

The wider systemic sclerosis / scleroderma progresses rapidly and affects a large part of the skin and one large part and one or more internal organs, often, the kidneys, compost hose, the heart and the lungs. This form of scleroderma may be disabled. There are no treatments for scleroderma, but the complexity of the individual organ system can be overcome. Other forms of scleroderma have systemic scleroderma, skin sclerosis and streptocytes, which lack the skin changes, but there are systemic manifestations and which affect the skin locally but not the internal organs.

Diagnosis is bad for the elderly, especially for men who suffer from wider dermal disease. Death from this disease is due to the complications of the lungs, heart and kidneys. In wider diarrheal disease, 5 years survival is 70%, and 10% survival 55%. The reason for this is unknown. Scleroderm is a family disease, but so far the genes have not been identified. Scleroderm affects the small blood vessel called arterica. First, the endometrium cells of the arteries die, along with a smooth muscle of cells also die by a process called apotoposis. They have collagen and other fibrous material in their place. Inflammatory cells, especially CD4 + T helper cells, infiltrate the arteries, thereby causing further damage. Many inflammatory and destructive protein signals have been identified and they are potential targets of those medicines, which can be interrupted for the process.

Classification

Scleroderma shows areas of colored or rigid, smooth, smooth, ivory-colored areas which are fixed and which resemble hyddound skin patients, a disease that occurs in both localized and form.

Rough diarrhea overflows the skin atrophy Systemic scleroderma Diagnosis of disease

Typical scleroderma is a symmetrical thickening of the skin, as it is defined, in which 90% of cases have been detected in Raenaur, nail-type, capillary changes and anti-nuclear antibodies. Patients may or may not have experience of systemic organ participation. In irregular scleroderma, any of these changes can appear without the change of skin, as well as with finger swelling. The extra symptoms of scleroderma are usually present within two years of the rayonaur phenomenon.

Anti-totoisomerase antibodies (from which a broad systemic form) or anti-situosomer antibodies (from which there is a limited systemic form and crest syndrome) can show anti-laboratory testing. Other autoantibodies such as anti-U3 or anti-RNA polymerase can be seen.

Serious complications which include squarrodda: the treatment

There is no direct treatment for scleroderma. Because the definitive cause is unknown, any treatment is patient-specific and is aimed at improving the symptoms of the disease. For example, patients who experience the Raenaur incident can be treated with agents who help in increasing blood flow from the fingers like indepidin, amlodipine, ditaliazem, felodipine or indestructible.

Skin fibrosis is treated with varying degrees of success by various agents such as Penicillamine-D, Colchicine, Pu, Relaxin and Cyclosporin.

Because scleroderma is an autoimmune disease, so the use of immunosuppressive agents is one of the main pillars of its treatment. These drugs include methotrexate, cyclophosphamide, azathioprine and mycophenolate.

In traditional Chinese medicine, scleroderma was treated as a problem of blood stagnation, lack of kidney and / or lack of spleen. Chinese herbal remedies include blood vitality, yang tonic, spleen qi tonic and warming agent. Forecast

Persons who have morphaya or limited squaredrodes have a relatively positive viewpoint. They will usually be victim of any other disease, not squiroderma. Having a very large amount of skin and organ involvement (systemic) can be a negative forecast. More women have scleroderma, but this disease has more men's moths. After diagnosis, two-thirds of the patients live for at least 11 years. At the time of diagnosis, if the age of the patient is over, then the disease is more likely to die.

Scleroderma patients may have very different life expectancy. Some- for example, those who have limited or mild widespread disease, after diagnosis, can expect to live 20 to 50 years, like anyone else. The other patient who is serious, who is progressive, is a progressive disease - a group that makes less than 10% of the total number of patients suffering from wider scleredodyma-they can get up to 50% chance of five years of life. / p> Epidemiology

This disease is found in all breeds around the world, but there is a possibility of scleroderma being developed in women compared to men. In the United States, about one in 1000 people is affected by this. Children rarely suffer systemic type, but local scleroderma is common in them. Most adults diagnose this disease after their 30th birthday and before 50 years of age. The high rate of the disease has been observed among the native American Choktaw tribe and American African women. History

The case of skin disease, which is similar to scleroderma can be found in the writings of Hippocrates, which was found in 460-370 BC. Is old Orbius (325-403 AD) and Paul Agineta (625-690 CE) also wrote on this subject. It is difficult for us to know that these were really examples of Scleroderma because their description is not sufficient.

The first definitive description of this disease was done in a nogramoff in Naples published in Naples by Naples Loans in 1753. This account produced great interest in French and English medical circles.

The account was about a 17-year-old journalist named Gallia, who was admitted to the hospital and handed over to Dr. Karz. His symptoms, in the doctor's speech, are described by the hardness of the skin (which was recorded in different degrees), tightness around the mouth and hardness around the neck. He mentioned loss of skin in the heat but did not find any other problem in pulse, respiration, or digestion.

In many parts of the report there is a description of the treatment, including hot milk and steam bath, blood flowing through the foot and small dose of para. After 11 months, the skin became soft and flexible and all natural functions were restored.

The comments of the loans were published in French in 1755 and they were very interested in designing loans in R. William, (1808) in London and his own student GL Albert, (1818), in the related texts. Observation has been done. Additional images Also see them

साँचा:Localized connective tissue diseases साँचा:Systemic connective tissue disorders

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